Mouse Monoclonal Antibody to CCND1

Item#:

sAP-0412

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0412
Product Name	Mouse Monoclonal Antibody to CCND1
Target Molecle	CCND1
Aliases	BCL1; PRAD1; U21B31; D11S287E; CCND1
Species	Human
MW	33.7kDa
Enterez GeneID	595
General Information	During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by acting as regulatory subunits of the Cdks. Early in the G1 phase of the cell cycle, cyclin D1 induction is followed by cyclin E induction. This sequential progression is marked early on in G1 by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB. The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2. In a recent study, Cyclin D1 regulates cellular metabolism, fat cell differentiation and cellular migration. Cyclin D1 is also involved in development and cancer. Cyclin D1 has also been linked to the development and progression of several cancers including breast, bladder, esophagus, and lung.
Immunogen	Purified recombinant fragment of human CCND1 expressed in E. Coli. ;
Clone	MM3D8;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Exp Cell Res. 2004 Oct 15;300(1)