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Mouse Monoclonal Antibody to IHOG
Item#:
sAP-0410
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0410
Product Name Mouse Monoclonal Antibody to IHOG
Target Molecle IHOG
Aliases CG9211; CT26314; Dmel\CG9211; ihog; Ihog
Species Drosophila melanogaster
MW 98kDa
Enterez GeneID 33972
General Information The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.
Immunogen Purified recombinant fragment of human IHOG expressed in E. Coli.
Clone MM3G8;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Cancer Lett. 2010 Jan 1;287(1)
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