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Mouse Monoclonal Antibody to CDC2
Item#:
sAP-0393
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0393
Product Name Mouse Monoclonal Antibody to CDC2
Target Molecle CDC2
Aliases CDC2; CDC28A; P34CDC2; MGC111195; DKFZp686L20222; CDK1
Species Human
MW 34kDa
Enterez GeneID 983
General Information The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.
Immunogen Purified recombinant fragment of CDC2 expressed in E. Coli.
Clone MM8C5A7F10;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Rie, M.A. de, J. of Immunol. Methods, 1987. 102
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