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Mouse Monoclonal Antibody to RAG2
Item#:
sAP-0384
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0384
Product Name Mouse Monoclonal Antibody to RAG2
Target Molecle RAG2
Aliases RAG-2; RAG2
Species Human
MW 59kDa
Enterez GeneID 5897
General Information This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Immunogen Purified recombinant fragment of human RAG2(350-527aa) expressed in E. Coli.
Clone MM4D5;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide. ;
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. J Neurosci Res. 1992 Feb;31(2)
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