Mouse Monoclonal Antibody to MAP2K2

Item#:

sAP-0362

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0362
Product Name	Mouse Monoclonal Antibody to MAP2K2
Target Molecle	MAP2K2
Aliases	MEK2; MKK2; MAPKK2
Species	Human; Mouse; Rat
MW	44kDa
Enterez GeneID	5605
General Information	MAP2K2, also called MEK2, it is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.
Immunogen	Purified recombinant fragment of human MAP2K2 expressed in E. Coli.
Clone	MM7F5;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. J Biol Chem. 1992 Feb 5;267(4)