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Mouse Monoclonal Antibody to GSK3B
Item#:
sAP-0359
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0359
Product Name Mouse Monoclonal Antibody to GSK3B
Target Molecle GSK3B
Aliases GSK-3ß; GSK3-beta
Species Human; Mouse; Monkey; Rat;
MW 46kDa
Enterez GeneID 2932
General Information Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription factors and structural proteins, and is part of the signal transduction cascade of a large number of growth factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt
Immunogen Purified recombinant fragment of human GSK3B expressed in E. Coli.;
Clone MM3D10;
Isotype Mouse IgG2a
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Biochem Biophys Res Commun. 2007 Dec 14;364(2)
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