Mouse Monoclonal Antibody to Pirh2

Item#:

sAP-0358

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0358
Product Name	Mouse Monoclonal Antibody to Pirh2
Target Molecle	Pirh2
Aliases	ARNIP; CHIMP; RNF199; RCHY1
Species	Human; Rat
MW	30kDa; 60kDa (homodimer)
Enterez GeneID	25898
General Information	Pirh 2 (P53 induced RING-H2 protein), also known as RCHY1, it forms dimers through its N- and C-terminus in cells. The Pirh2 has ubiquitin-protein ligase activity and it binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. The Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 expression decreases the level of p53, and a decrease of endogenous Pirh2 expression increases p53 levels. Pirh2 is therefore considered, together with MDM2, to act as a negative regulator of p53 function.
Immunogen	Purified recombinant fragment of human Pirh2 expressed in E. Coli.
Clone	MM1H10;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Hepatology. 1998 Apr;27(4)