Mouse Monoclonal Antibody to ATP2C1

Item#:

sAP-0354

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0354
Product Name	Mouse Monoclonal Antibody to ATP2C1
Target Molecle	ATP2C1
Aliases	HHD; BCPM; PMR1; SPCA1
Species	Human; Monkey
MW	100kDa
Enterez GeneID	27032
General Information	ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
Immunogen	Purified recombinant fragment of ATP2C1 expressed in E. Coli.
Clone	MM4G12;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. J Cell Physiol. 2010 Oct;225(1)