Mouse Monoclonal Antibody to ABL2

Item#:

sAP-0349

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0349
Product Name	Mouse Monoclonal Antibody to ABL2
Target Molecle	ABL2
Aliases	ARG; ABLL; FLJ22224; FLJ31718; FLJ41441
Species	Human; Mouse
MW	128kDa
Enterez GeneID	27
General Information	ABL2 (ARG, Abl-related gene), together with c-Abl, forms the Abl family of mammalian non-receptor tyrosine kinases. ABL2 and c-Abl share 89%, 90 and 93% identity in their SH3, SH2 and tyrosine domain, but only 29% identity in the carboxy-terminal half. The human c-Abl and ABL2 genes are expressed ubiquitously. ABL2 had been detected predominantly in the cytoplasm, whereas c-Abl shows both cytoplasmic and nuclear localization. c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl. Recently, TEL-ARG fusion transcripts have also been identified in acute myeloid leukemias (AML). The Abl family kinases may also interact with receptor tyrosine signaling pathways and regulate cellular function such as cell cycle progression, gene transcription and organization of the actin cytoskeletons in neurons.
Immunogen	Purified recombinant fragment of ABL2 expressed in E. Coli.
Clone	MM1H1;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Cell Death Differ. 2007 Jul;14(7)