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Mouse Monoclonal Antibody to SMC1
Item#:
sAP-0346
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0346
Product Name Mouse Monoclonal Antibody to SMC1
Target Molecle SMC1
Aliases SMC1; SMCB; CDLS2; SB1.8; SMC1L1; DXS423E; KIAA0178; MGC138332; SMC1alpha; DKFZp686L19178; SMC1A
Species Human;
MW 143kDa
Enterez GeneID 8243
General Information Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.
Immunogen Purified recombinant fragment of human SMC1 expressed in E. Coli. ;
Clone MM5B6;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Biochem Biophys Res Commun. 2008 Dec 19;377(3)
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