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Mouse Monoclonal Antibody to NGFR
Item#:
sAP-0342
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0342
Product Name Mouse Monoclonal Antibody to NGFR
Target Molecle NGFR
Aliases CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; NGFR
Species Human
MW 45kDa
Enterez GeneID 4804
General Information Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).
Immunogen Purified recombinant fragment of human NGFR expressed in E. Coli.
Clone MM2F1C2;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Yamada, K. et al. (1997) Diabetologia. 40(6)
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