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Mouse Monoclonal Antibody to CTNNB1
Item#:
sAP-0337
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0337
Product Name Mouse Monoclonal Antibody to CTNNB1
Target Molecle CTNNB1
Aliases CTNNB; FLJ25606; FLJ37923; DKFZp686D02253; CTNNB1
Species Human
MW 85kDa
Enterez GeneID 1499
General Information The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.
Immunogen Purified recombinant fragment of human CTNNB1 expressed in E. Coli.
Clone MM4D5;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Proc Natl Acad Sci USA. 1993. 90(22)
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