Mouse Monoclonal Antibody to Metadherin

Item#:

sAP-0332

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0332
Product Name	Mouse Monoclonal Antibody to Metadherin
Target Molecle	Metadherin
Aliases	3D3; AEG1; LYRIC; MTDH
Species	Human
MW	64kDa
Enterez GeneID	92140
General Information	Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
Immunogen	Purified recombinant fragment of human Metadherin expressed in E. Coli.
Clone	MM2F11C3;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Antibody are purified by protein G affinity chromatography. ; Liquid in PBS containing 50% glycerol and 0.03% sodium azide. ;
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Nature. 1997 Aug 7;388(6642)