Mouse Monoclonal Antibody to PTEN

Item#:

sAP-0328

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0328
Product Name	Mouse Monoclonal Antibody to PTEN
Target Molecle	PTEN
Aliases	BZS; MHAM; TEP1; PTEN1
Species	Human; Mouse;
MW	54kDa
Enterez GeneID	5728
General Information	PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. This protein is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
Immunogen	Purified recombinant fragment of PTEN expressed in E. Coli.
Clone	MM1B8;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Nature. 1999 Jun 10;399(6736)