Mouse Monoclonal Antibody to CD40

Item#:

sAP-0304

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0304
Product Name	Mouse Monoclonal Antibody to CD40
Target Molecle	CD40
Aliases	p50; Bp50; CDW40; TNFRSF5
Species	Human
MW	N/A
Enterez GeneID	958
General Information	CD40 molecule, TNF receptor superfamily member 5. It is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Immunogen	Purified recombinant fragment of CD40 expressed in E. Coli.
Clone	MM9G10;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Am J Pathol. 2002 Dec;161(6)