Mouse Monoclonal Antibody to GATA4

Item#:

sAP-0301

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0301
Product Name	Mouse Monoclonal Antibody to GATA4
Target Molecle	GATA4
Aliases	MGC126629
Species	Human; Rat;
MW	46kDa
Enterez GeneID	2626
General Information	GATA binding protein 4, also known as GATA4, it is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.
Immunogen	Purified recombinant fragment of human GATA4 expressed in E. Coli.
Clone	MM6H10;
Isotype	Mouse IgG2b
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3)