Mouse Monoclonal Antibody to MUSK

Item#:

sAP-0287

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0287
Product Name	Mouse Monoclonal Antibody to MUSK
Target Molecle	MUSK
Aliases	muscle, skeletal, receptor tyrosine kinase
Species	Human
MW	97kDa
Enterez GeneID	4593
General Information	MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.
Immunogen	Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.
Clone	MM10A4;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Microcirculation. 2008 Aug;15(6)