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Mouse Monoclonal Antibody to R-spondin1
Item#:
sAP-0258
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0258
Product Name Mouse Monoclonal Antibody to R-spondin1
Target Molecle R-spondin1
Aliases RSPO1;CRISTIN3;FLJ40906
Species Human
MW 28.9kDa
Enterez GeneID 284654
General Information R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Immunogen Purified recombinant fragment of R-spondin1 expressed in E. Coli. ;
Clone MM7A6;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Leukemia. 2008 Dec;22(12)
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