Home Page > ANTIBODY > MONOCLONAL ANTIBODY > Mouse Monoclonal Antibody >  Mouse Monoclonal Antibody to IKBKE

Mouse Monoclonal Antibody to IKBKE
Item#:
sAP-0145
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0145
Product Name Mouse Monoclonal Antibody to IKBKE
Target Molecle IKBKE
Aliases IKBKE
Species Human
MW N/A
Enterez GeneID 9641
General Information Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon.The transcription factor NF?B is retained in the cytoplasm in an inactive form by the inhibitory protein I?B. Activation of NF?B requires that I?B be phosphorylated on specific serine residues, which results in targeted degra-dation of I?B. I?B kinase a(IKKa), previously designated CHUK, interacts with I?B-aand specifically phosphorylates I?B-aon the sites that trigger its degradation, serines 32 and 36. The functional IKK complex contains three subunits, IKKa, IKKßand IKK?(also designated NEMO), and each appear to make essential contributions to I?B phosphorylation. IKK-i is a serine/threonine kinase that shares homology with IKKaand IKKß. IKK-i is pri-marily expressed in immune cells and is induced by lipopolysaccharide and by proinflammatory cytokines including TNFa, IL-1 and IL-6. Overexpression of IKK-i was shown to result in phosphorylation of I?Baon Ser32 and Ser36, and in NF?B activation, suggesting that IKK-i may act as an I?B kinase in the immune system.
Immunogen Purified recombinant fragment of IKBKE (aa1-257) expressed in E. Coli.
Clone MM6B4B5;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Am J Surg Pathol. 2007 Sep;31(9)
N
N

ANGIO-PROTEOMIE, ALL RIGHTS RESERVED