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Mouse Monoclonal Antibody to DDR2
Item#:
sAP-0124
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0124
Product Name Mouse Monoclonal Antibody to DDR2
Target Molecle DDR2
Aliases TKT; MIG20a; NTRKR3; TYRO10
Species Human
MW N/A
Enterez GeneID 4921
General Information DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.
Immunogen Purified recombinant fragment of human DDR2 expressed in E. Coli.
Clone MM3B11E4;
Isotype Mouse IgG2a
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Scherzer CR. Offe K. Gearing M. et al. Arch Neurol. 2004, Aug, 61(8)
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