Mouse Monoclonal Antibody to PRAK

Item#:

sAP-0120

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0120
Product Name	Mouse Monoclonal Antibody to PRAK
Target Molecle	PRAK
Aliases	PRAK; MAPKAPK5
Species	Human
MW	N/A
Enterez GeneID	8550
General Information	PRAK (p38-regulated /activated kinase), also referred to as mitogen-activated protein kinase (MAPK)-activated protein kinase (MAPKAPK)-5, is an ubiquitously expressed serine/threonine kinase regulated by p38a and p38ß MAP kinases. Activated JNK, p38? or p38d are unable to induce phosphorylation of PRAK in vitro. Phosphorylation of PRAK occurs in vivo in response to p38 activation by stress-related extracellular stimuli including UV light, oxidation and proinflammatory cytokines. Two other substrates for p38, MAPKAPK-2 and MAPKAPK-3/3pK, share approximately 45% sequence homology with PRAK including the phosphorylation motif recognized by p38, Lys-X-Thr-Pro. Activated PRAK has been shown to specifically phosphorylate HSP 27 in vitro, suggesting that the protein may play a role in stress-induced small heat shock protein phosphorylation in vivo.
Immunogen	Purified recombinant fragment of PRAK expressed in E. Coli.
Clone	MM7H10B4;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Delfino FJ. Stevenson H. Smithgall TE. J Biol Chem. 2006, Mar 31, 281(13)