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Mouse Monoclonal Antibody to ER
Item#:
sAP-0112
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0112
Product Name Mouse Monoclonal Antibody to ER
Target Molecle ER
Aliases ER; ESR; Era; ESRA; NR3A1; DKFZp686N23123; ESR1
Species Human
MW N/A
Enterez GeneID 2099
General Information ER (estrogen receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites. Serines 104, 106, 118 and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serines plays an important role in regulating ER activity. Ser118 may be the substrate of the transcription regulatory kinase cdK7. Ser167 may be phosphorylated by p90RSK and Akt. Phosphorylation of Ser167 may confer tamoxifen resistance in breast cancer patients.
Immunogen Purified recombinant fragment of ER expressed in E. Coli.
Clone MM5D4B1;
Isotype Mouse IgG2b
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Adams, T.E. et al. Cell. Mol. Life Sci. 2000 57, 1050-1093. ; 2. Baserga, R. et al. Oncogene 2000 19, 5574-5581. ; 3. Scheidegger, K.J. et al. J. Biol. Chem. 2000 275, 38921-38928. ;
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