Mouse Monoclonal Antibody to Human P16

Item#:

sAP-0110

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0110
Product Name	Mouse Monoclonal Antibody to Human P16
Target Molecle	Human P16
Aliases	Human P16
Species	Human;
MW	N/A
Enterez GeneID	1029
General Information	p16 (cyclin-dependent kinase inhibitor 2A, INK4a) is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 / Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16 INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16 INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16 INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia.
Immunogen	Purified recombinant fragment of P16 expressed in E. Coli.
Clone	MM5A8A4;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Alcorta, D.A., et al. 1989. Mol. Cell. Biol. 9