Mouse Monoclonal Antibody to GSK3 alpha

Item#:

sAP-0106

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0106
Product Name	Mouse Monoclonal Antibody to GSK3 alpha
Target Molecle	GSK3 alpha
Aliases	DKFZp686D0638; GSK3A
Species	Human
MW	N/A
Enterez GeneID	2931
General Information	Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
Immunogen	Purified recombinant fragment of GSK3 alpha expressed in E. Coli.
Clone	MM9D5G1;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Yamada, N., et al. Biochem. Biophys. Res. Commun. 192