Mouse Monoclonal Antibody to AURKB

Item#:

sAP-0089

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0089
Product Name	Mouse Monoclonal Antibody to AURKB
Target Molecle	AURKB
Aliases	AURKB
Species	Human
MW	N/A
Enterez GeneID	9212
General Information	AURKB (aurora kinase B, AIK2 or aurora-B), with 344-amino acid protein(about 39kDa),localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB is a mitotic protein kinase, which phosphorylates histone H3 and regulates Chromosomal segregation during mitosis and meiosis.It may regulates several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis.Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. ARK-2 transcripts arepresent at high levels in human thymus and fetal liver.ARK-2 protein levels are maximal during both S and G2/M phases
Immunogen	Purified recombinant fragment of AURKB expressed in E. Coli.
Clone	MM13E8D3;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Azoitei N,et al. Biochemistry. 2005.14;44(23)