Mouse Monoclonal Antibody to IKBKB

Item#:

sAP-0088

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0088
Product Name	Mouse Monoclonal Antibody to IKBKB
Target Molecle	IKBKB
Aliases	IKBKB
Species	Human
MW	N/A
Enterez GeneID	3551
General Information	IKBKB(Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.
Immunogen	Purified recombinant fragment of IKBKB expressed in E. Coli.
Clone	MM10A2C5B3;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Azoitei N,et al. Biochemistry. 2005.14;44(23)