Mouse Monoclonal Antibody to 4E-BP1

Item#:

sAP-0083

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0083
Product Name	Mouse Monoclonal Antibody to 4E-BP1
Target Molecle	4E-BP1
Aliases	BP-1; 4EBP1; 4E-BP1; PHAS-I; MGC4316; EIF4EBP1
Species	Human
MW	N/A
Enterez GeneID	1978
General Information	4E-BP1(eukaryotic translation Initiation Factor 4E Binding Protein 1),also called ELF4EBP1/BP-1/PHAS-I ,which is located on chromosome 8p12, with 118-amino acid protein (about 13kDa). Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation status of eIF4EBP1. Non phosphorylated eIF4EBP1 will bind strongly to eIF4E while(24kDa), the phosphorylated form will not. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction.
Immunogen	Purified recombinant fragment of 4EBP1 expressed in E. Coli.
Clone	MM11G12C11;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Purified antibody in PBS containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Pause, A. et al. 1994.Nature. 371