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Mouse Monoclonal Antibody to ER-alpha
Item#:
sAP-0040
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0040
Product Name Mouse Monoclonal Antibody to ER-alpha
Target Molecle ER-alpha
Aliases ER; ESR1; Era; ESRA
Species Human
MW N/A
Enterez GeneID 2099
General Information The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ER mRNA transcripts, which differ primarily in their 5-prime untranslated regions. Two isoforms of the human ER, ERA and ER-beta, occur, each with distinct tissue and cell patterns of expression. Pelletier and El-Alfy (2000) studied the immunocytochemical localization of ESRA and ESRB in human reproductive tissues. In the ovary, ERB immunoreactivity was found in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, interstitial gland, and germinal epithelium cells. Nuclear staining for ERA occurred in thecal, interstitial gland, and germinal epithelium cells. In the uterus, strong ERA immunoreactivity was detected in nuclei of epithelial, stromal, and muscle cells.
Immunogen Purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. Coli.
Clone MM2B7;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Purified antibody in PBS containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. JR Goldenring, KR Shen, HD Vaughan. et al. J. Biol. Chem,1993,268(25)

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