Mouse Monoclonal Antibody to RB

Item#:

sAP-0031

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0031
Product Name	Mouse Monoclonal Antibody to RB
Target Molecle	RB
Aliases	RB; pRb; OSRC; pp110; p105-Rb; RB1
Species	Human
MW	N/A
Enterez GeneID	5925
General Information	The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).
Immunogen	Purified recombinant fragment of human RB expressed in E. Coli.
Clone	MM7E4B8;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. EMBO J. 1998. 16