Mouse Monoclonal Antibody to MCL-1

Item#:

sAP-0027

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0027
Product Name	Mouse Monoclonal Antibody to MCL-1
Target Molecle	MCL-1
Aliases	EAT, MCL1L, MCL1S
Species	Human
MW	37kDa
Enterez GeneID	4170
General Information	Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.
Immunogen	Purified recombinant fragment of human MCL-1 expressed in E. Coli. ;
Clone	MM8C6;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Purified antibody in PBS containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Exp. Cell Res. 1995. 218