Mouse Monoclonal Antibody to MSH2

Item#:

sAP-0025

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0025
Product Name	Mouse Monoclonal Antibody to MSH2
Target Molecle	MSH2
Aliases	FCC1; COCA1; HNPCC; LCFS2
Species	Human; Monkey
MW	105kDa
Enterez GeneID	4436
General Information	MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50% of inherited non-polyposis colorectal (HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process.
Immunogen	Purified recombinant fragment of human MSH2 expressed in E. Coli.
Clone	MM1B3;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Clevers,H.Annu.Rev.Immun.6