Goat anti-HMGCR / LDLCQ3 Antibody

Item#:

dAP-1757

Size	Price	Quantity
50.0 ug	$310.00

Goat anti-HMGCR / LDLCQ3 Antibody
Principle Name	HMGCR / LDLCQ3
Official Symbol	HMGCR
All Name and Symbols	HMGCR; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; LDLCQ3; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl-CoA reductase; HMG-CoA reductase
Accession Number(s)	NP_000850.1
Peptide Sequence	ADPSPQNSTADTSK , is from internal region
Human Gene ID(s)	3156
Non-Human GeneID(s)
Important Comments
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Supplied As	lyophilized powder of 50ug or 100ug IgG; Reconsititute IgG with 100ul or 200ul sterile DI Water and final product will be formulated as 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Applications	Pep ELISA
Tested Species
Peptide ELISA	antibody detection limit dilution 1 to 8000.
Western Blot	Preliminary experiments in Human Brain (Cerebellum), Liver, Skeletal Muscle and Adipose lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any feedback from people in the field -
Reference(s)	Hanai J, Cao P, Tanksale P, Imamura S, Koshimizu E, Zhao J, Kishi S, Yamashita M, Phillips PS, Sukhatme VP, Lecker SH. The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. J Clin Invest. 2007 Dec;117(12)