Goat anti-ACVR1 Antibody |
| Principle Name | ACVR1 |
| Official Symbol | ACVR1 |
| All Name and Symbols | ACVR1; activin A receptor, type I; ACTRI; ACVRLK2; ALK2; FOP; SKR1; activin A receptor, type II-like kinase 2; activin A type I receptor; hydroxyalkyl-protein kinase |
| Accession Number(s) | NP_001096.1 |
| Peptide Sequence | RKFKRRNQERLNPRD, is from internal region |
| Human Gene ID(s) | 90 |
| Non-Human GeneID(s) | 11477 (mouse); 79558 (rat); |
| Important Comments | Reported variants represent identical protein |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Supplied As | lyophilized powder of 50ug or 100ug IgG; Reconsititute IgG with 100ul or 200ul sterile DI Water and final product will be formulated as 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Aliquot and store at -20°C. Minimize freezing and thawing. |
| Applications | Pep ELISA, WB, IHC |
| Tested Species | Human |
| Peptide ELISA | antibody detection limit dilution 1 to 128000. |
| Western Blot | Approx 60kDa band observed in Human Umbilical Cord lysates (calculated MW of 57.2kDa according to NP_001096.1). Recommended concentration |
| Immunohistochemistry | In paraffin embedded Human Testis shows preferential staining of cytoplasm in primary spermatocytes.. Recommended concentration, 4-6µg/ml. |
| Reference(s) | Shore EM, Xu M, Feldman GJ, Fenstermacher DA, Cho TJ, Choi IH, Connor JM, Delai P, Glaser DL, LeMerrer M, Morhart R, Rogers JG, Smith R, Triffitt JT, Urtizberea JA, Zasloff M, Brown MA, Kaplan FS. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet. 2006 May;38(5) |
