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Goat anti-SHP2 / PTPN11 Antibody
Item#:
dAP-0334
Size Price Quantity
50.0 ug $310.00
Goat anti-SHP2 / PTPN11 Antibody
Principle Name SHP2 / PTPN11
Official Symbol PTPN11
All Name and Symbols PTPN11; SHP2; protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1); CFC; NS1; BPTP3; PTP2C; SHP-2; PTP-1D; SH-PTP2; SH-PTP3; Noonan syndrome 1; protein-tyrosine phosphatase 2C; protein tyrosine phosphatase, non-receptor type 11; MGC14433
Accession Number(s) NP_002825.3
Peptide Sequence YENVGLMQQQKSFR, is from C Terminus
Human Gene ID(s) 5781
Non-Human GeneID(s) 19247 (mouse); 25622 (rat);
Important Comments
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Supplied As lyophilized powder of 50ug or 100ug IgG; Reconsititute IgG with 100ul or 200ul sterile DI Water and final product will be formulated as 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Applications Pep ELISA, WB, IHC
Tested Species Human, Mouse
Peptide ELISA antibody detection limit dilution 1 to 32000.
Western Blot Approx 70kDa band observed in Human Skeletal Muscle lysates and in lysates of cell line HEK293 (calculated MW of 68.0kDa according to NP_002825.3). In transfected HEK293 transiently expressing PTPN11 bands of approx. 70kDa and 49kDa are obs
Immunohistochemistry In paraffin embedded Human Cerebellum shows strong cytoplasm staining in Purkinje cells and processes. Recommended concentration, 3-6µg/ml.
Reference(s) Saxton TM, Ciruna BG, Holmyard D, Kulkarni S, Harpal K, Rossant J, Pawson T. The SH2 tyrosine phosphatase shp2 is required for mammalian limb development. Nat Genet 2000 Apr;24(4)

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