Mouse Monoclonal Antibody to RET

Item#:

sAP-0132

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0132
Product Name	Mouse Monoclonal Antibody to RET
Target Molecle	RET
Aliases	RET
Species	Human
MW	N/A
Enterez GeneID	5979
General Information	RET (ret proto-oncogene) is a member of the cadherin superfamily and a receptor tyrosine kinase, which are cell-surface molecules that transduce signals for cell growth and differentiation. It can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung¿s disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.
Immunogen	Purified recombinant fragment of RET (aa896-1063) expressed in E. Coli.
Clone	MM8D10C9;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Dawson A. Struthers AD. Expert Opin Biol Ther. 2003, Feb, 3(1)