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Mouse Monoclonal Antibody to BCL-10
Item#:
sAP-0003
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0003
Product Name Mouse Monoclonal Antibody to BCL-10
Target Molecle BCL-10
Aliases CLAP; Me10; CIPER; c-E10; CARMEN
Species Human; Mouse
MW 26kDa
Enterez GeneID 8915
General Information Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Immunogen Purified recombinant fragment of human BCL-10 expressed in E. Coli.
Clone MM4F8;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Purified antibody in PBS containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Roitt,I, et al "Immunology", Mosby, London, England, (1996) fourth edition. ; 2. Vlug, A. et al "The structure and function of human IgG subclasses". Eur.Clin.Lab. 8, 26 (1989). ;

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