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Mouse Monoclonal Antibody to CD45


Item#:
sAP-0247B
Size Price Quantity
100.0 ug $341.00
Catalog Number sAP-0247B
Product Name Mouse Monoclonal Antibody to CD45
Target Molecule CD45
Aliases LCA; LY5; B220; CD45; T200; CD45R; GP180; PTPRC
Species Human
MW N/A
Enterez GeneID 5788
General Information CD45, also known as TPRC(protein tyrosine phosphatase, receptor type, C). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Immunogen Purified recombinant fragment of CD45 expressed in E. Coli. ; ;
Clone MM1B9B10;
Isotype Mouse IgG2b
Size and Concentration 100ug (1mg/ml)
Supplied As Lyophilized Powder from 100ul of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstituted with 100ul sterile DI H2O, at stored at 4C or -20C for short or long-term storage.
Applications ELISA
References 1. Lung Cancer. 2007 Dec;58(3)

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