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Mouse Monoclonal Antibody to ACVR1


Item#:
sAP-1576
Size Price Quantity
100.0 ug $341.00
Catalog Number sAP-1576
Product Name Mouse Monoclonal Antibody to ACVR1
Target Molecle ACVR1
Aliases FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2
Species Human;
MW 57.2kDa
Enterez GeneID 90
General Information Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
Immunogen Purified recombinant fragment of human ACVR1 (AA
Clone MM2E2C11
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1.Expert Opin Ther Targets. 2015 Feb;19(2)

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