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Mouse Monoclonal Antibody to UHRF1


Item#:
sAP-1455
Size Price Quantity
100.0 ug $341.00
Catalog Number sAP-1455
Product Name Mouse Monoclonal Antibody to UHRF1
Target Molecle UHRF1
Aliases PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1
Species Human;
MW 148.5kDa
Enterez GeneID 5335
General Information This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.;
Immunogen Purified recombinant fragment of human UHRF1 (AA
Clone MM2A8C7;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1.Cancer Discov. 2014 Apr;4(4)

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