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Mouse Monoclonal Antibody to SMAD1


Item#:
sAP-1365
Size Price Quantity
50.0 ug $245.00
100.0 ug $320.00
Catalog Number sAP-1365
Product Name Mouse Monoclonal Antibody to SMAD1
Target Molecle SMAD1
Aliases BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1
Species Human; Mouse; Monkey;
MW 52kDa
Enterez GeneID 4086
General Information The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.;
Immunogen Purified recombinant fragment of human SMAD1 (AA
Clone MM4E12H10;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1.Cancer Lett. 2015 Jan 28;356(2 Pt B)
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