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Mouse Monoclonal Antibody to CD274


Item#:
sAP-1363
Size Price Quantity
50.0 ug $245.00
Catalog Number sAP-1363
Product Name Mouse Monoclonal Antibody to CD274
Target Molecle CD274
Aliases B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1
Species Human;
MW 33.3kDa
Enterez GeneID 29126
General Information This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.;
Immunogen Purified recombinant fragment of human CD274 (AA
Clone MM7D2A10;
Isotype Mouse IgG2b
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1.J Virol. 2013 Aug;87(16)
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