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Mouse Monoclonal Antibody to AKT1


Item#:
sAP-1332
Size Price Quantity
50.0 ug $245.00
Catalog Number sAP-1332
Product Name Mouse Monoclonal Antibody to AKT1
Target Molecle AKT1
Aliases AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
Species Human; Mouse; Monkey; Rat;
MW 55.7kDa
Enterez GeneID 207
General Information The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. ;
Immunogen Purified recombinant fragment of human AKT1 (AA
Clone MM1F7E10;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1.Placenta. 2015 Apr;36 Suppl 1
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