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Mouse Monoclonal Antibody to DNMT3L


Item#:
sAP-1325
Size Price Quantity
50.0 ug $245.00
100.0 ug $320.00
Catalog Number sAP-1325
Product Name Mouse Monoclonal Antibody to DNMT3L
Target Molecle DNMT3L
Aliases
Species Human;
MW 43.6kDa
Enterez GeneID 29947
General Information CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.;
Immunogen Purified recombinant fragment of human DNMT3L (AA
Clone MM2D10H11;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1.Clin Cancer Res. 2010 May 15;16(10)
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